Fused-Core® columns can deliver both fast and high resolution separations that allow chromatographers to choose the best combination of particle size and column geometry appropriate for their methods and their instrumentation. The application of 2 μm columns using appropriate instrumentation provides more separation power than previously available using 2.7 μm SPP columns. For ultra-fast, high-throughput separations of samples in 96–384 well plates, ultra-high resolution separations of impurities in new and generic pharmaceuticals, complex environmental sample separations and challenging LC-MS separations, Fused-Core columns can deliver superior results, both accurately and reproducibly, in a timely manner.