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Technical Support

Requesting Technical Support

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Recommended Practices for Starting Off Successfully With a Brand-New Column

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Recommended Practices for Successful Column Flushing and Storage

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Column Cleaning Recommendations

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Modernization of 5 um Chinese Pharmacopeia (CP) HPLC Methods for High Throughput Laboratories

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White Papers

HILIC Analysis for Polar Modifications of Proteins and Peptides

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HILIC Analysis for Polar Modifications of mAbs

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Analysis of Nitrosamines in APIs

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Getting the Best Out of Solid-Core Technology for Small and Large Molecule Analysis

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Avantor® Hichrom GC Product Bulletin

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Maintaining LC Column Performance

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Analysis of the Oxidation of NIST mAb Fragment Using HILIC and HRAM MS

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Allowable Changes to USP and Pharmacopoeia Monograph LC Methods

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The Use of Mobile Phase pH as a Method Development Tool

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300 A Wide Pore HPLC Columns for the Separation and Purification of Proteins

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Euerby-Modified Tanaka Plots of HALO Reversed Phase Small Molecule Chemistries

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Selectivity and Stability Review of HALO® Fused-Core Columns

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Achieving Superior Separations with Innovative Chromatography Technologies

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Selectivity and Resolution Advantages of Superficially Porous Particles with C30 Stationary Phase

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Adapting Well Known Chromatographic Techniques for the Analysis of Biomolecules

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Best Practices for Limiting Hazardous Solvent Exposure with Safety Caps and Waste Containment for HPLC and UHPLC Systems

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Making Good Connections with the Improved Avantor Ultrasphere Column Hardware

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Avantor® ACE® Excel-Bioanalytical Oligo Buffer Recommendations

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UHPLC & HPLC Method Development for Pharmaceutical-Related Substance

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Resolution, Sensitivity, and Stability for Method Screening

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Fat- and Water-Soluble Vitamin Analysis in Supplements

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Chromatography Solutions for the Analysis of Nitrosamines

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Reducing Particle Size, Column ID, and Length to Increase Throughput Using SPP Columns with Sidenafil Case Study

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Catalogs

Avantor® ACE® Excel 1.7 um Catalog

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New HILIC Bonded-Phase Fused-Core Columns Demonstrating Highly Efficient Separations

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MAC-MOD® SafetyCaps Material Data Sheet

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Reversed-Phase Method Development Flow Chart

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HILIC Method Development Flow Chart

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HPLC and UHPLC System Shutdown and Reactivation Advice

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Column Regeneration for Partisil and Partisphere Ion-Exchange Columns

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Column Cleaning, Regeneration and Storage of Silica-Based Columns

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USP Column Codes

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Transferring LC Methods Between Different Instruments

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The Effect of Sample Diluent on Peak Shape

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Analyte Properties – pKa, logP and logD

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Increasing HPLC and UHPLC Sample Throughput – Doing More in Less Time

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Technical Reports

FDA LC-MS-MS Method for the Determination of NDMA in Ranitidine

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FDA Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) Method for the Determination of NDMA in Ranitidine Drug Substance and Drug Product

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High Resolution Separation of BSA Tryptic Digest

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Catalogs

UltraSphere® Catalog

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New Phases With Additional Selectivity for Method Development and the Analysis of Small Molecules

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Achieving Successful Method Translations in Liquid Chromatography

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A Novel Approach to Glycan Method Development for Biotherapeutics using Superficially Porous Particle Technology

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Webinars

Best Practices for Limiting Hazardous Solvent Exposure with SafetyCaps and Waste Containment for HPLC and UHPLC Systems

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RPLC Method Development Strategies Using Stationary Phase and Mobile Phase Screening, and Some Helpful Tools and Tips

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Avantor® ACE® Catalog

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LC and LC-MS of Intact Protein Biotherapeutics and their Variants and Panel Discussion With Industry Experts

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The Importance of Superficially Porous Particles in Modernizing HPLC Methods

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Accelerated Method Development with Novel Stationary Phase Chemistries

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LC Method Development Using a Unified Column Screening and Retention Modeling Approach

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Factors That Can Affect the Stability, Performance, and Lifetime of Silica-based RPLC Columns

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LabNotes

Method Development Using Solid-Core Particle Columns

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LabNotes

An Overview of Systematic RPLC Method Development Using Multiple Organic Modifiers and Different pH Buffers

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Webinars

Using Selectivity to Optimize Resolution for Improved LC and LC-MS Method Development

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UHPLC and HPLC Method Development for Pharmaceutical-Related Substances

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Theory and Practice of Developing LC Methods with Solid-Core Particle Columns

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LC and LC-MS of Intact Protein Biotherapeutics and their Variants and Panel Discussion

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HILIC Practical Tips and Guidance for Method Development

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Exploiting pH as a Part of Your RPLC Method Development Strategy

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A Streamlined Approach for Reversed-Phase Method Development Using Combined Column Screening and Software Modeling

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Posters

Exploring HPLC and UHPLC Chromatographic Selectivity With Low and High pH Eluents

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Larger Superficially Porous Particles – The Long and Short of it for HPLC Separations

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Particle Size Considerations of Superficially Porous Particles

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Exploring Low And High pH Eluents Using A New Silica-Based Extended pH Range C18 Column For Analysis Of Amphetamines and Opiates From Urine By LC-MS-MS

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Exploring The Power Of Chromatographic Selectivity For Polar & Non-Polar Analytes With A Unique HPLC-UHPLC Polar Embedded Stationary Phase

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Presentations

Speed and Resolution with 5-Micron Superficially Porous Particles

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Chromatographic Effects Of Varying Particle Size And Size Distributions Of Superficially Porous Particles

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Novel Hydrophilic Bonded-Phase Fused-Core Particles for Highly Efficient HILIC Separations

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Considerations and Best Practices for Mobile Phase Buffer Selection and pH Control for LC and LC-MS Method Development

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Avantor® ACE® UltraCore Catalog

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HALO® Application Guide

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Avantor® ACE® Complete Application Guide

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Working With UHPLC – Accelerating Method Development, Speeding Up Routine Analyses, and Achieving Ultra High Resolution

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Understanding and Overcoming Separation Challenges in the Biological Drug Development Process

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Take Your UHPLC and HPLC Methods to the Next Level of Speed and Resolution

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Application Packets

Avantor® ACE® UHPLC Application Packet

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Application Packets

Avantor® ACE® Pharmaceutical Application Packet

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Application Packets

Avantor® ACE® Monograph Application Packet

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Avantor® ACE® LCMS Application Packet

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Technical Reports

Troubleshooting Guide by John Dolan

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Modifying Agilent 1100 HPLC Systems to Achieve “UHPLC-like” Performance With HALO® Fused-Core® Particles

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How to Measure and Reduce HPLC Equipment Extra Column Volume

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Separation of Paracetamol and Related Substances following European Pharmacopoeia Method 9.4

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A Conversation on Retention and Resolution

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Buffer Selection Guide by John Dolan

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Guide to Labelling Mobile Phase Buffers

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Using Narrow Bore Columns to Enhance Sensitivity for LC-UV and LC-MS Analyses

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Gradient Method Translation using the Avantor® ACE® Translation Tool

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Solid-Core Technology

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How to Determine Extra Column Dispersion and Extra Column Volume

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How to Determine Column Volume and Particle Porosity

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Understanding the Relationship Between Particle Size, Performance and Pressure

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Technical Support

Avantor® ACE® SuperC18 Buffer Recommendations

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Practical Ultra High Performance Liquid Chromatography (UHPLC)

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Chromatographic Band Broadening and the van Deemter Equation