Abstract
Geoff Faden discusses the significant improvement in raw performance (N, Efficiency Term) the chromatographer can leverage when utilizing an HPLC column optimized and packed with monodisperse fully porous particle silica-based columns denoted as MFPP.
By significantly reducing the Eddy Diffusion also known as “A” Term in the Van Deemter equation, the innovation in LC particle technology reduces the HETP (height equivalent to a theoretical plate) which increases performance from 25-60% when compared to traditional polydisperse silica-based columns.
The data presented displays the 50% reduction in D90/D10 using a Coulter Counter as well as SEM images that visually represent the Monodisperse Particle Technology. Chromatographic and MS data are shown that display the significant efficiency increases that the MFPP based silica columns generate.