In all types of modern laboratories, it is increasingly important to be able to carry out accurate and reproducible HPLC analyses with excellent turnaround time and throughput. For those laboratories that must develop, validate, and use methods over a significant period of time, or those that must transfer methods to other laboratories around the world, it is a practical business advantage to be able to develop robust and rugged methods more quickly. For both of these situations, it can be beneficial to have a diverse group of column chemistries from which one can choose and use to explore chromatographic selectivity.